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Semaglutide is a novel long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. GLP-1, a hormone secreted by the intestines, lowers blood glucose and promotes weight loss through multiple mechanisms: it enhances insulin secretion in a glucose concentration-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces food intake via central appetite suppression.
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Semaglutide mimics the action of endogenous GLP-1, a hormone involved in glucose homeostasis and appetite regulation. By binding to GLP-1 receptors, it:




